We explored the effects of probiotic LC-STH-13 on systemic lupus erythematosus (SLE) in MRL/lpr mice. Our study demonstrated that LC-STH-13 significantly decreased harmful autoantibodies and rebalanced specific immune cells.
We also observed reduced immune cell infiltration in kidney tissue, indicating less inflammation. Furthermore, the probiotic helped restore healthy gut microbiota which gets disrupted by SLE. These findings suggest that LC-STH-13 may offer a novel way to manage lupus by targeting both immune regulation and gut health.
Read More
9
Lactobacillus acidophilus shows promise in autoimmune management
New Lactobacillus acidophilus isolates reduce the release of leptin by murine adipocytes leading to lower interferon-gamma production.
We explored how specific Lactobacillus acidophilus strains can impact autoimmune disorders by reducing leptin production in mice. In our study, we compared the effects of CBA4P and other lactobacilli on adipocytes from mice sensitive to Th1 immune diseases.
Results showed that CBA4P significantly lowered leptin levels and inhibited the activation of immune lymphocytes in the SJL mouse strain. This suggests that CBA4P might help manage Th1-related inflammatory conditions, representing a potentially valuable probiotic option for autoimmune control.
We investigated the effects of Lactobacillus rhamnosus GG (LGG) in combating inflammation and cellular changes caused by gliadin in celiac disease models. Our study found that pretreating intestinal cells with LGG postbiotics stopped the activation of harmful pathways linked to gliadin, such as mTOR and NF-κβ. Notably, this protective effect was also observed in more complex models using organoids derived from celiac patients. While these findings are promising, further research is necessary to fully understand LGG’s potential benefits in managing celiac disease.
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Most Useful Reviews
9
Effective for improvement
1 people found this helpful
Works effectively! I ordered the third batch and take them with breaks of 2-3 weeks. I had an autoimmune disorder linked to my gastrointestinal tract, which returned after stopping breastfeeding. However, since taking this prebiotic, my symptoms have improved.
Read More
9
Preventative measure taken
1 people found this helpful
Good probiotics! In my first pregnancy, I faced issues like constipation and haemorrhoids. For my second pregnancy, I decided to take these probiotics early, and from 20 weeks onwards, they've helped keep my intestines functioning well.
Read More
9
Positive microbiota support
1 people found this helpful
Excellent probiotic! I took it throughout my pregnancy and didn't experience thrush, unlike many others. Maintaining a good microbiota is crucial for passing beneficial bacteria to my baby. I recommend it; it worked wonders for me!
We examined how a special probiotic mix, known as IRT5, affects autoimmune diabetes in non-obese diabetic (NOD) mice. Administered frequently over 36 weeks, this combination not only reduced diabetes incidence but also lowered insulitis scores and increased insulin-producing β-cell mass.
Additionally, IRT5 improved gut health and changed the makeup of immune cells in the pancreas and intestines. While some immune responses stayed the same, the shift towards more gut-focused regulatory T cells suggests it could be a promising treatment for type 1 diabetes.
Read More
9
Synbiotics improve rheumatoid arthritis symptoms
Synbiotic supplementation and the effects on clinical and metabolic responses in patients with rheumatoid arthritis: a randomised, double-blind, placebo-controlled trial.
We investigated how synbiotic supplementation affects patients with rheumatoid arthritis (RA). In an 8-week, randomized, double-blind trial involving 54 participants, we compared the outcomes of those taking synbiotic capsules with a placebo group.
After the trial, those who received synbiotics showed a significant drop in inflammation markers and pain levels. Additionally, improvements were observed in insulin resistance and overall metabolic responses.
These findings suggest that synbiotics might benefit individuals managing RA by reducing inflammation and enhancing metabolic health.
Read More
9
Lactobacillus acidophilus shows promise in autoimmune management
New Lactobacillus acidophilus isolates reduce the release of leptin by murine adipocytes leading to lower interferon-gamma production.
We explored how specific Lactobacillus acidophilus strains can impact autoimmune disorders by reducing leptin production in mice. In our study, we compared the effects of CBA4P and other lactobacilli on adipocytes from mice sensitive to Th1 immune diseases.
Results showed that CBA4P significantly lowered leptin levels and inhibited the activation of immune lymphocytes in the SJL mouse strain. This suggests that CBA4P might help manage Th1-related inflammatory conditions, representing a potentially valuable probiotic option for autoimmune control.
Read More
9
Probiotics may aid rheumatoid arthritis
The Impacts of and to Promote In Vitro Anti-Inflammatory Profile of RA-Macrophages.
We examined how probiotics, specifically Lactobacillus rhamnosus, could help with rheumatoid arthritis (RA) symptoms. By isolating monocytes from RA patients and healthy individuals, we created macrophages and tested various treatments.
Our findings revealed that probiotics encouraged macrophages to adopt a more anti-inflammatory state. They increased beneficial cytokines while lowering inflammatory ones. This suggests a potential role for probiotics in managing RA, showing they might help modulate immune responses and improve symptoms.
Read More
9
LC-STH-13 counters lupus effects
LC-STH-13 ameliorates the progression of SLE in MRL/lpr mice by inhibiting the TLR9/NF-κB signaling pathway.
We explored the effects of probiotic LC-STH-13 on systemic lupus erythematosus (SLE) in MRL/lpr mice. Our study demonstrated that LC-STH-13 significantly decreased harmful autoantibodies and rebalanced specific immune cells.
We also observed reduced immune cell infiltration in kidney tissue, indicating less inflammation. Furthermore, the probiotic helped restore healthy gut microbiota which gets disrupted by SLE. These findings suggest that LC-STH-13 may offer a novel way to manage lupus by targeting both immune regulation and gut health.
Works effectively! I ordered the third batch and take them with breaks of 2-3 weeks. I had an autoimmune disorder linked to my gastrointestinal tract, which returned after stopping breastfeeding. However, since taking this prebiotic, my symptoms have improved.
Read More
9
Preventative measure taken
1 people found this helpful
Good probiotics! In my first pregnancy, I faced issues like constipation and haemorrhoids. For my second pregnancy, I decided to take these probiotics early, and from 20 weeks onwards, they've helped keep my intestines functioning well.
Read More
9
Positive microbiota support
1 people found this helpful
Excellent probiotic! I took it throughout my pregnancy and didn't experience thrush, unlike many others. Maintaining a good microbiota is crucial for passing beneficial bacteria to my baby. I recommend it; it worked wonders for me!
Read More
9
Digestive benefits noted
Excelente! Recommended by my nutritionist, I've taken these daily for 3 weeks and feel considerably less bloated with easier digestion. The capsules are tasteless and perfectly sized at just one per day. I’ll definitely order again.
Read More
9
Quick benefits experienced
Excellent! After researching for digestion improvements during pregnancy, we chose this brand. The quality is impressive, the capsules are the right size, and the results were almost immediate. The price was unbeatable, and the delivery was quick.
An autoimmune disorder occurs when the body's immune system mistakenly attacks its own healthy cells and tissues, believing them to be foreign invaders, such as bacteria or viruses. This reaction can lead to inflammation, tissue damage, and impaired function of the affected organs. There are over 80 known autoimmune diseases, including rheumatoid arthritis, lupus, multiple sclerosis, and type 1 diabetes, each with its own specific symptoms and treatment options. The exact cause of these disorders is still unclear, but a combination of genetic, environmental, and hormonal factors is believed to play a role in their development.
Diagnosis of autoimmune disorders often involves a combination of physical examinations, assessment of symptoms, blood tests, and imaging studies to evaluate organ involvement. Treatment typically focuses on managing symptoms and controlling the immune response using medications such as corticosteroids, immunosuppressants, and biologics. In addition to medication, lifestyle modifications, such as stress management and a balanced diet, can be beneficial in managing symptoms. If you suspect you have an autoimmune condition, it's important to consult a healthcare professional for proper evaluation and tailored treatment options.
Pre and post-natal formulas are specialized dietary supplements designed to support the nutritional needs of women during pregnancy and postpartum recovery. Pre-natal formulas typically include a combination of essential vitamins and minerals, such as folic acid, iron, and calcium, to promote the health of both mother and developing baby. These nutrients are crucial for fetal development, reducing the risk of complications, and supporting the overall well-being of expectant mothers.
Post-natal formulas, on the other hand, focus on replenishing nutrients that may have been depleted during pregnancy and childbirth and enhancing recovery after delivery. They often contain additional nutrients to support breastfeeding, such as DHA and omega-3 fatty acids, which are important for infant brain development. Both types of formulas aim to ensure that mothers have the necessary nutrients for their health and their babies' development, making them an essential part of pre and post-natal care.
Based on user reviews, the time it takes to see results from this supplement can vary significantly. Some users reported experiencing improvements in symptoms as soon as a few weeks after starting the regimen. For instance, one reviewer mentioned feeling considerably less bloated and having easier digestion after taking it daily for just three weeks Read Review. Another user noted that they saw "almost immediate" results in terms of digestion improvements during their pregnancy Read Review.
However, not all users had the same experience, with some reporting no effects even after completing the entire package Read Review. Another reviewer stated that they did not experience any improvement at all after their trial Read Review. Overall, while many users see benefits within a few weeks, it's important to remember that individual results can vary widely from person to person.
The research data supports the use of probiotics, specifically certain strains like Lactobacillus and Bifidobacterium, as potentially beneficial for managing various autoimmune disorders. For instance, a study involving Lactobacillus acidophilus demonstrated improvements in symptoms of systemic lupus erythematosus (SLE), particularly through a decrease in inflammatory markers and enhanced immune cell regulation [2]. Additionally, Lactobacillus acidophilus has shown promise in alleviating multiple sclerosis (MS) symptoms by improving gut health and reducing oxidative stress [1]. Moreover, synbiotics including these probiotics have been found to lower inflammatory markers and improve disease activity in SLE patients [2].
Other studies also highlight benefits of probiotics in autoimmune conditions like rheumatoid arthritis and autoimmune diabetes, where they helped to reduce inflammation and improve metabolic responses [5]. Particularly, multiple studies confirm the potential of Lactobacillus rhamnosus and Bifidobacterium longum in enhancing immune tolerance and reducing symptoms associated with autoimmune disorders. While the initial findings are promising, more comprehensive research is needed to refine these applications and understand the underlying mechanisms involved. Overall, the evidence indicates a strong basis for considering probiotics as a complementary option in the management of autoimmune disorders.
Based on user reviews, many individuals have reported significant improvements in their gastrointestinal symptoms after using this prebiotic. One user, who suffered from an autoimmune disorder related to their gastrointestinal tract, noted that their symptoms have markedly improved since starting the supplement Read Review. Other users experienced prevention and relief from common pregnancy-related issues such as constipation and thrush. One reviewer shared that by taking the probiotics early in her second pregnancy, she managed to avoid constipation and maintained better digestive health Read Review, while another mentioned not experiencing thrush, which is frequently reported by others during pregnancy Read Review.
Conversely, it's important to note that individual experiences vary. Some users reported no improvement at all, even after consistent use of the product, leading them to seek out alternative solutions Read Review. One reviewer even mentioned clinical issues that arose after taking the product, suggesting it may not be universally effective Read Review. While the positive anecdotes can be encouraging, they underscore the variability in individual results and the potential need for personalized approaches when selecting probiotics.
Based on user reviews, many individuals have reported that combining this supplement with other probiotics or supplements can yield various results when managing autoimmune disorders. One user, who dealt with gastrointestinal issues from an autoimmune condition, reported significant improvements since incorporating this prebiotic into their routine, specifically after periods of taking 2-3 week breaks Read Review. Another review highlighted that taking these probiotics during pregnancy helped maintain digestive health and prevent common issues like constipation Read Review.
However, not all experiences were positive. Some users shared that they noticed little to no improvement when using this supplement, prompting them to seek alternatives Read Review. Additionally, one reviewer mentioned experiencing adverse effects that they attributed to potential issues with the product rather than its efficacy Read Review. This variability suggests that results can differ significantly, and users considering combining this supplement with others should proceed with caution and possibly consult healthcare professionals to tailor their approach to their specific health needs.
Based on user reviews, it appears that the right dosage for Pre Post Natal Formulas varies among individuals when it comes to treating autoimmune disorders. One user reported success in managing their autoimmune symptoms effectively by taking the prenatal probiotics in cycles, with breaks of 2-3 weeks between doses Read Review. In contrast, other users had mixed experiences, with some noting a lack of improvement even after completing the recommended dosage. For instance, one user stated that they experienced no benefits after finishing the jar Read Review.
While some reviewers did express satisfaction with their results, indicating that consistent daily use led to digestive improvements during pregnancy Read Review, it’s evident that dosage may need to be tailored to individual responses. Hence, users might find it necessary to experiment with their intake frequency and duration to determine the most effective dosage for their unique situations. Overall, feedback suggests a personalized approach is essential in finding the right balance.
9
Digestive benefits noted
Excelente! Recommended by my nutritionist, I've taken these daily for 3 weeks and feel considerably less bloated with easier digestion. The capsules are tasteless and perfectly sized at just one per day. I’ll definitely order again.
9
Quick benefits experienced
Excellent! After researching for digestion improvements during pregnancy, we chose this brand. The quality is impressive, the capsules are the right size, and the results were almost immediate. The price was unbeatable, and the delivery was quick.
0
Did not help
I experienced bloating troubles. After consuming the entire package, I noticed no improvement. I ordered a second one but still saw no results, so I opted for other more expensive probiotics.
2
No effect noted
Unfortunately, the expected effect was absent. I finished the jar but will not order it again. I give three stars for the brand, deducting two for the lack of impact.
9
Effective for improvement
1 people found this helpful
Works effectively! I ordered the third batch and take them with breaks of 2-3 weeks. I had an autoimmune disorder linked to my gastrointestinal tract, which returned after stopping breastfeeding. However, since taking this prebiotic, my symptoms have improved.
9
Preventative measure taken
1 people found this helpful
Good probiotics! In my first pregnancy, I faced issues like constipation and haemorrhoids. For my second pregnancy, I decided to take these probiotics early, and from 20 weeks onwards, they've helped keep my intestines functioning well.
9
Positive microbiota support
1 people found this helpful
Excellent probiotic! I took it throughout my pregnancy and didn't experience thrush, unlike many others. Maintaining a good microbiota is crucial for passing beneficial bacteria to my baby. I recommend it; it worked wonders for me!
0
Not effective
1 people found this helpful
Did not help. I experienced a disorder instead. I suspect the bacteria might have been poorly stored and ineffective. In my view, sourcing live bacteria from local pharmacies is preferable and could be more beneficial.
8
Synbiotics reduce lupus activity
Impact of synbiotics on disease activity in systemic lupus erythematosus: Results from a randomized clinical trial.
This randomized, double-blind trial sought to see how synbiotics, including Lactobacillus acidophilus, could help patients with systemic lupus erythematosus (SLE). Fifty patients were divided into two groups: one received synbiotics alongside their standard therapy, while the other got standard therapy alone over two months.
We observed that those who took the synbiotics showed a meaningful drop in inflammatory markers like interleukin-17A and overall disease activity. Meanwhile, the placebo group didn’t see these improvements. While these findings are promising, we recognize that more research is necessary to fully understand how synbiotics work in SLE management.
8
Lactic acid bacteria combat autoimmune symptoms
The Role of Lactic Acid Bacteria in Improving Behavioral Deficits, Serum Levels of Vitamin D3, B12 and Reducing Oxidative Stress and Demyelination in a Cuprizone-induced Demyelination Model of Rat.
We investigated the potential of Lactobacillus and Bifidobacterium in alleviating symptoms of multiple sclerosis using a rat model. The study involved 48 male rats, which were divided into groups to evaluate the effects of these bacteria on demyelination caused by cuprizone.
The results showed that treatment with lactic acid bacteria notably improved behavioral impairments, decreased demyelination, reduced oxidative stress, and elevated serum levels of vitamins D and B.
Overall, these findings indicate that Lactobacillus and Bifidobacterium may be beneficial in managing autoimmune conditions like multiple sclerosis.
7
Probiotics improve inflammation in RA
Mixture of probiotics reduces inflammatory biomarkers and improves the oxidative/nitrosative profile in people with rheumatoid arthritis.
We examined how a mix of probiotics, including Lactobacillus acidophilus, affects inflammation in people with rheumatoid arthritis (RA). In a double-blind study with 42 participants, we found that those taking probiotics had lower white blood cell counts and reduced levels of specific inflammatory markers.
While our results showed improvements in oxidative stress profiles, such as higher antioxidant levels, some inflammatory markers remained unchanged. Overall, probiotic supplementation appears to offer benefits for managing RA through reduced inflammation and improved oxidative status.
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Javanmardi Z, Mahmoudi M, Rafatpanah H, Rezaieyazdi Z, Shapouri-Moghaddam A, et al. Tolerogenic probiotics Lactobacillus delbrueckii and Lactobacillus rhamnosus promote anti-inflammatory profile of macrophages-derived monocytes of newly diagnosed patients with systemic lupus erythematosus. Cell Biochem Funct. 2024;42:e3981. doi:10.1002/cbf.3981
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Hoseinzadeh A, Mahmoudi M, Rafatpanah H, Rezaieyazdi Z, Tavakol Afshari J, et al. A new generation of mesenchymal stromal/stem cells differentially trained by immunoregulatory probiotics in a lupus microenvironment. Stem Cell Res Ther. 2023;14:358. doi:10.1186/s13287-023-03578-z
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Furone F, Bellomo C, Carpinelli M, Nicoletti M, Hewa-Munasinghege FN, et al. The protective role of GG postbiotic on the alteration of autophagy and inflammation pathways induced by gliadin in intestinal models. Front Med (Lausanne). 2023;10:1085578. doi:10.3389/fmed.2023.1085578
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Wang CH, Yen HR, Lu WL, Ho HH, Lin WY, et al. Adjuvant Probiotics of subsp. AP-32, MH-68, and subsp. CP-9 Attenuate Glycemic Levels and Inflammatory Cytokines in Patients With Type 1 Diabetes Mellitus. Front Endocrinol (Lausanne). 2022;13:754401. doi:10.3389/fendo.2022.754401
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Salehipour Z, Haghmorad D, Sankian M, Rastin M, Nosratabadi R, et al. Bifidobacterium animalis in combination with human origin of Lactobacillus plantarum ameliorate neuroinflammation in experimental model of multiple sclerosis by altering CD4+ T cell subset balance. Biomed Pharmacother. 2017;95:1535. doi:10.1016/j.biopha.2017.08.117
Ezendam J, de Klerk A, Gremmer ER, van Loveren H. Effects of Bifidobacterium animalis administered during lactation on allergic and autoimmune responses in rodents. Clin Exp Immunol. 2008;154:424. doi:10.1111/j.1365-2249.2008.03788.x