Overview

SCIENTIFIC SCORE
Moderately Effective
Based on 39 Researches
8
USERS' SCORE
Moderately Good
Based on 12 Reviews
7
Supplement Facts
Serving Size:  1 Capsule
Amount Per Serving
%DV
Prenatal Probiotic BlendLactobacillus rhamnosusLactobacillus rhamnosus HN001Lactobacillus acidophilusLactobacillus plantarumLactobacillus paracaseiLactobacillus brevisLactobacillus bulgaricusLactobacillus caseiLactobacillus gasseriLactobacillus reuteriLactobacillus salivariusTotal Lacto Cultures (15 Billion CFU)Bifidobacterium longumBifidobacterium infantisBifidobacterium bifidumBifidobacterium breveBifidobacterium lactisTotal Bifido Cultures (5 Billion CFU)
170 mg
+
Total Probiotic Cultures
20 Billion CFU¹
 
Organic Prebiotic Fiber BlendOrganic Potato (Resistant Starch] (tuber), Organic Acacia Fiber (A. senegal)
115 mg
+

Top Medical Research Studies

9
LC-STH-13 counters lupus effects
We explored the effects of probiotic LC-STH-13 on systemic lupus erythematosus (SLE) in MRL/lpr mice. Our study demonstrated that LC-STH-13 significantly decreased harmful autoantibodies and rebalanced specific immune cells.

We also observed reduced immune cell infiltration in kidney tissue, indicating less inflammation. Furthermore, the probiotic helped restore healthy gut microbiota which gets disrupted by SLE. These findings suggest that LC-STH-13 may offer a novel way to manage lupus by targeting both immune regulation and gut health.
Read More
9
Lactobacillus acidophilus shows promise in autoimmune management
We explored how specific Lactobacillus acidophilus strains can impact autoimmune disorders by reducing leptin production in mice. In our study, we compared the effects of CBA4P and other lactobacilli on adipocytes from mice sensitive to Th1 immune diseases.

Results showed that CBA4P significantly lowered leptin levels and inhibited the activation of immune lymphocytes in the SJL mouse strain. This suggests that CBA4P might help manage Th1-related inflammatory conditions, representing a potentially valuable probiotic option for autoimmune control.
Read More
9
Lactobacillus rhamnosus mitigates gliadin's effects
We investigated the effects of Lactobacillus rhamnosus GG (LGG) in combating inflammation and cellular changes caused by gliadin in celiac disease models. Our study found that pretreating intestinal cells with LGG postbiotics stopped the activation of harmful pathways linked to gliadin, such as mTOR and NF-κβ. Notably, this protective effect was also observed in more complex models using organoids derived from celiac patients. While these findings are promising, further research is necessary to fully understand LGG’s potential benefits in managing celiac disease.
Read More

Most Useful Reviews

9
Effective for improvement
1 people found this helpful
Works effectively! I ordered the third batch and take them with breaks of 2-3 weeks. I had an autoimmune disorder linked to my gastrointestinal tract, which returned after stopping breastfeeding. However, since taking this prebiotic, my symptoms have improved.
Read More
9
Preventative measure taken
1 people found this helpful
Good probiotics! In my first pregnancy, I faced issues like constipation and haemorrhoids. For my second pregnancy, I decided to take these probiotics early, and from 20 weeks onwards, they've helped keep my intestines functioning well.
Read More
9
Positive microbiota support
1 people found this helpful
Excellent probiotic! I took it throughout my pregnancy and didn't experience thrush, unlike many others. Maintaining a good microbiota is crucial for passing beneficial bacteria to my baby. I recommend it; it worked wonders for me!
Read More

Medical Researches

SCIENTIFIC SCORE
Moderately Effective
Based on 39 Researches
8
  • All Researches
9
Probiotic IRT5 reduces diabetes effects
We examined how a special probiotic mix, known as IRT5, affects autoimmune diabetes in non-obese diabetic (NOD) mice. Administered frequently over 36 weeks, this combination not only reduced diabetes incidence but also lowered insulitis scores and increased insulin-producing β-cell mass.

Additionally, IRT5 improved gut health and changed the makeup of immune cells in the pancreas and intestines. While some immune responses stayed the same, the shift towards more gut-focused regulatory T cells suggests it could be a promising treatment for type 1 diabetes.
Read More
9
Synbiotics improve rheumatoid arthritis symptoms
We investigated how synbiotic supplementation affects patients with rheumatoid arthritis (RA). In an 8-week, randomized, double-blind trial involving 54 participants, we compared the outcomes of those taking synbiotic capsules with a placebo group.

After the trial, those who received synbiotics showed a significant drop in inflammation markers and pain levels. Additionally, improvements were observed in insulin resistance and overall metabolic responses.

These findings suggest that synbiotics might benefit individuals managing RA by reducing inflammation and enhancing metabolic health.
Read More
9
Lactobacillus acidophilus shows promise in autoimmune management
We explored how specific Lactobacillus acidophilus strains can impact autoimmune disorders by reducing leptin production in mice. In our study, we compared the effects of CBA4P and other lactobacilli on adipocytes from mice sensitive to Th1 immune diseases.

Results showed that CBA4P significantly lowered leptin levels and inhibited the activation of immune lymphocytes in the SJL mouse strain. This suggests that CBA4P might help manage Th1-related inflammatory conditions, representing a potentially valuable probiotic option for autoimmune control.
Read More
We examined how probiotics, specifically Lactobacillus rhamnosus, could help with rheumatoid arthritis (RA) symptoms. By isolating monocytes from RA patients and healthy individuals, we created macrophages and tested various treatments.

Our findings revealed that probiotics encouraged macrophages to adopt a more anti-inflammatory state. They increased beneficial cytokines while lowering inflammatory ones. This suggests a potential role for probiotics in managing RA, showing they might help modulate immune responses and improve symptoms.
Read More
9
LC-STH-13 counters lupus effects
We explored the effects of probiotic LC-STH-13 on systemic lupus erythematosus (SLE) in MRL/lpr mice. Our study demonstrated that LC-STH-13 significantly decreased harmful autoantibodies and rebalanced specific immune cells.

We also observed reduced immune cell infiltration in kidney tissue, indicating less inflammation. Furthermore, the probiotic helped restore healthy gut microbiota which gets disrupted by SLE. These findings suggest that LC-STH-13 may offer a novel way to manage lupus by targeting both immune regulation and gut health.
Read More

User Reviews

USERS' SCORE
Moderately Good
Based on 12 Reviews
7
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Effective for improvement
1 people found this helpful
Works effectively! I ordered the third batch and take them with breaks of 2-3 weeks. I had an autoimmune disorder linked to my gastrointestinal tract, which returned after stopping breastfeeding. However, since taking this prebiotic, my symptoms have improved.
Read More
9
Preventative measure taken
1 people found this helpful
Good probiotics! In my first pregnancy, I faced issues like constipation and haemorrhoids. For my second pregnancy, I decided to take these probiotics early, and from 20 weeks onwards, they've helped keep my intestines functioning well.
Read More
9
Positive microbiota support
1 people found this helpful
Excellent probiotic! I took it throughout my pregnancy and didn't experience thrush, unlike many others. Maintaining a good microbiota is crucial for passing beneficial bacteria to my baby. I recommend it; it worked wonders for me!
Read More
9
Digestive benefits noted
Excelente! Recommended by my nutritionist, I've taken these daily for 3 weeks and feel considerably less bloated with easier digestion. The capsules are tasteless and perfectly sized at just one per day. I’ll definitely order again.
Read More
9
Quick benefits experienced
Excellent! After researching for digestion improvements during pregnancy, we chose this brand. The quality is impressive, the capsules are the right size, and the results were almost immediate. The price was unbeatable, and the delivery was quick.
Read More

Frequently Asked Questions

9
Digestive benefits noted
Excelente! Recommended by my nutritionist, I've taken these daily for 3 weeks and feel considerably less bloated with easier digestion. The capsules are tasteless and perfectly sized at just one per day. I’ll definitely order again.
9
Quick benefits experienced
Excellent! After researching for digestion improvements during pregnancy, we chose this brand. The quality is impressive, the capsules are the right size, and the results were almost immediate. The price was unbeatable, and the delivery was quick.
0
Did not help
I experienced bloating troubles. After consuming the entire package, I noticed no improvement. I ordered a second one but still saw no results, so I opted for other more expensive probiotics.
2
No effect noted
Unfortunately, the expected effect was absent. I finished the jar but will not order it again. I give three stars for the brand, deducting two for the lack of impact.
9
Effective for improvement
1 people found this helpful
Works effectively! I ordered the third batch and take them with breaks of 2-3 weeks. I had an autoimmune disorder linked to my gastrointestinal tract, which returned after stopping breastfeeding. However, since taking this prebiotic, my symptoms have improved.
9
Preventative measure taken
1 people found this helpful
Good probiotics! In my first pregnancy, I faced issues like constipation and haemorrhoids. For my second pregnancy, I decided to take these probiotics early, and from 20 weeks onwards, they've helped keep my intestines functioning well.
9
Positive microbiota support
1 people found this helpful
Excellent probiotic! I took it throughout my pregnancy and didn't experience thrush, unlike many others. Maintaining a good microbiota is crucial for passing beneficial bacteria to my baby. I recommend it; it worked wonders for me!
0
Not effective
1 people found this helpful
Did not help. I experienced a disorder instead. I suspect the bacteria might have been poorly stored and ineffective. In my view, sourcing live bacteria from local pharmacies is preferable and could be more beneficial.
This randomized, double-blind trial sought to see how synbiotics, including Lactobacillus acidophilus, could help patients with systemic lupus erythematosus (SLE). Fifty patients were divided into two groups: one received synbiotics alongside their standard therapy, while the other got standard therapy alone over two months.

We observed that those who took the synbiotics showed a meaningful drop in inflammatory markers like interleukin-17A and overall disease activity. Meanwhile, the placebo group didn’t see these improvements. While these findings are promising, we recognize that more research is necessary to fully understand how synbiotics work in SLE management.
8
Lactic acid bacteria combat autoimmune symptoms
We investigated the potential of Lactobacillus and Bifidobacterium in alleviating symptoms of multiple sclerosis using a rat model. The study involved 48 male rats, which were divided into groups to evaluate the effects of these bacteria on demyelination caused by cuprizone.

The results showed that treatment with lactic acid bacteria notably improved behavioral impairments, decreased demyelination, reduced oxidative stress, and elevated serum levels of vitamins D and B.

Overall, these findings indicate that Lactobacillus and Bifidobacterium may be beneficial in managing autoimmune conditions like multiple sclerosis.
7
Probiotics improve inflammation in RA
We examined how a mix of probiotics, including Lactobacillus acidophilus, affects inflammation in people with rheumatoid arthritis (RA). In a double-blind study with 42 participants, we found that those taking probiotics had lower white blood cell counts and reduced levels of specific inflammatory markers.

While our results showed improvements in oxidative stress profiles, such as higher antioxidant levels, some inflammatory markers remained unchanged. Overall, probiotic supplementation appears to offer benefits for managing RA through reduced inflammation and improved oxidative status.

References

  1. Kazemimiraki M, Moazamian E, Mokhtari MJ, Gholamzad M. The Role of Lactic Acid Bacteria in Improving Behavioral Deficits, Serum Levels of Vitamin D3, B12 and Reducing Oxidative Stress and Demyelination in a Cuprizone-induced Demyelination Model of Rat. Neuromolecular Med. 2025;27:14. doi:10.1007/s12017-025-08837-1
  2. Mirfeizi Z, Mahmoudi M, Jokar MH, Sahebari M, Noori E, et al. Impact of synbiotics on disease activity in systemic lupus erythematosus: Results from a randomized clinical trial. J Food Sci. 2024;89:9835. doi:10.1111/1750-3841.17460
  3. Woo JS, Hwang SH, Yang S, Lee KH, Lee YS, et al. Lactobacillus acidophilus and propionate attenuate Sjögren's syndrome by modulating the STIM1-STING signaling pathway. Cell Commun Signal. 2023;21:135. doi:10.1186/s12964-023-01141-0
  4. Kim DS, Park Y, Choi JW, Park SH, Cho ML, et al. Supplementation Exerts a Synergistic Effect on Tacrolimus Efficacy by Modulating Th17/Treg Balance in Lupus-Prone Mice the SIGNR3 Pathway. Front Immunol. 2021;12:696074. doi:10.3389/fimmu.2021.696074
  5. Cannarella LAT, Mari NL, Alcântara CC, Iryioda TMV, Costa NT, et al. Mixture of probiotics reduces inflammatory biomarkers and improves the oxidative/nitrosative profile in people with rheumatoid arthritis. Nutrition. 2021;89:111282. doi:10.1016/j.nut.2021.111282
  6. Kim TK, Lee JC, Im SH, Lee MS. Amelioration of Autoimmune Diabetes of NOD Mice by Immunomodulating Probiotics. Front Immunol. 2020;11:1832. doi:10.3389/fimmu.2020.01832
  7. Kamal Y, Kandil M, Eissa M, Yousef R, Elsaadany B. Probiotics as a prophylaxis to prevent oral candidiasis in patients with Sjogren's syndrome: a double-blinded, placebo-controlled, randomized trial. Rheumatol Int. 2020;40:873. doi:10.1007/s00296-020-04558-9
  8. Kim J, Choi SH, Kim YJ, Jeong HJ, Ryu JS, et al. Clinical Effect of IRT-5 Probiotics on Immune Modulation of Autoimmunity or Alloimmunity in the Eye. Nutrients. 2017;9. doi:10.3390/nu9111166
  9. Tamtaji OR, Kouchaki E, Salami M, Aghadavod E, Akbari E, et al. The Effects of Probiotic Supplementation on Gene Expression Related to Inflammation, Insulin, and Lipids in Patients With Multiple Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Trial. J Am Coll Nutr. 2017;36:660. doi:10.1080/07315724.2017.1347074
  10. Zamani B, Farshbaf S, Golkar HR, Bahmani F, Asemi Z. Synbiotic supplementation and the effects on clinical and metabolic responses in patients with rheumatoid arthritis: a randomised, double-blind, placebo-controlled trial. Br J Nutr. 2017;117:1095. doi:10.1017/S000711451700085X
  11. Zamani B, Golkar HR, Farshbaf S, Emadi-Baygi M, Tajabadi-Ebrahimi M, et al. Clinical and metabolic response to probiotic supplementation in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled trial. Int J Rheum Dis. 2016;19:869. doi:10.1111/1756-185X.12888
  12. Bleau C, Lamontagne L, Savard R. New Lactobacillus acidophilus isolates reduce the release of leptin by murine adipocytes leading to lower interferon-gamma production. Clin Exp Immunol. 2005;140:427.
  13. Ahmadi P, Mahmoudi M, Rafatpanah H, Rezaieyazdi Z, Ahmadi-Khorram M, et al. The Impacts of and to Promote In Vitro Anti-Inflammatory Profile of RA-Macrophages. Food Sci Nutr. 2025;13:e70068. doi:10.1002/fsn3.70068
  14. Liao W, Zhang X, Jia C, Chen W, Cai Y, et al. LC-STH-13 ameliorates the progression of SLE in MRL/lpr mice by inhibiting the TLR9/NF-κB signaling pathway. Food Funct. 2025;16:475. doi:10.1039/d4fo03966a
  15. Javanmardi Z, Mahmoudi M, Rafatpanah H, Rezaieyazdi Z, Shapouri-Moghaddam A, et al. Tolerogenic probiotics Lactobacillus delbrueckii and Lactobacillus rhamnosus promote anti-inflammatory profile of macrophages-derived monocytes of newly diagnosed patients with systemic lupus erythematosus. Cell Biochem Funct. 2024;42:e3981. doi:10.1002/cbf.3981
  16. Vahidi Z, Saghi E, Mahmoudi M, RezaieYazdi Z, Esmaeili SA, et al. Lactobacillus rhamnosus and Lactobacillus delbrueckii Ameliorate the Expression of miR-125a and miR-146a in Systemic Lupus Erythematosus Patients. Appl Biochem Biotechnol. 2024;196:6330. doi:10.1007/s12010-023-04827-w
  17. Hoseinzadeh A, Mahmoudi M, Rafatpanah H, Rezaieyazdi Z, Tavakol Afshari J, et al. A new generation of mesenchymal stromal/stem cells differentially trained by immunoregulatory probiotics in a lupus microenvironment. Stem Cell Res Ther. 2023;14:358. doi:10.1186/s13287-023-03578-z
  18. Tripathy A, Swain N, Padhan P, Raghav SK, Gupta B. Lactobacillus rhamnosus reduces CD8T cell mediated inflammation in patients with rheumatoid arthritis. Immunobiology. 2023;228:152415. doi:10.1016/j.imbio.2023.152415
  19. Furone F, Bellomo C, Carpinelli M, Nicoletti M, Hewa-Munasinghege FN, et al. The protective role of GG postbiotic on the alteration of autophagy and inflammation pathways induced by gliadin in intestinal models. Front Med (Lausanne). 2023;10:1085578. doi:10.3389/fmed.2023.1085578
  20. Lin H, Lin J, Pan T, Li T, Jiang H, et al. Polymeric immunoglobulin receptor deficiency exacerbates autoimmune hepatitis by inducing intestinal dysbiosis and barrier dysfunction. Cell Death Dis. 2023;14:68. doi:10.1038/s41419-023-05589-3
  21. Samani SA, Moloudi MR, Ramezanzadeh R, Abdi M, Nikkhoo B, et al. Oral Administration of Probiotic to Ameliorate Experimental Autoimmune Encephalomyelitis in Mice. Basic Clin Neurosci. 2022;13:35. doi:10.32598/bcn.2021.1955.1
  22. Monzani R, Gagliardi M, Clemente N, Saverio V, Pańczyszyn E, et al. The Gut-Ex-Vivo System (GEVS) Is a Dynamic and Versatile Tool for the Study of DNBS-Induced IBD in BALB/C and C57BL/6 Mice, Highlighting the Protective Role of Probiotics. Biology (Basel). 2022;11. doi:10.3390/biology11111574
  23. Petersen AØ, Jokinen M, Plichta DR, Liebisch G, Gronwald W, et al. Cytokine-specific autoantibodies shape the gut microbiome in autoimmune polyendocrine syndrome type 1. J Allergy Clin Immunol. 2021;148:876. doi:10.1016/j.jaci.2021.03.025
  24. Liu Y, Hoang TK, Taylor CM, Park ES, Freeborn J, et al. and differentially affect gut microbes and metabolites in mice with Treg deficiency. Am J Physiol Gastrointest Liver Physiol. 2021;320:G969. doi:10.1152/ajpgi.00072.2021
  25. Fan Z, Yang B, Ross RP, Stanton C, Zhao J, et al. The prophylactic effects of different Lactobacilli on collagen-induced arthritis in rats. Food Funct. 2020;11:3681. doi:10.1039/c9fo02556a
  26. Khorasani S, Mahmoudi M, Kalantari MR, Lavi Arab F, Esmaeili SA, et al. Amelioration of regulatory T cells by Lactobacillus delbrueckii and Lactobacillus rhamnosus in pristane-induced lupus mice model. J Cell Physiol. 2019;234:9778. doi:10.1002/jcp.27663
  27. Mardani F, Mahmoudi M, Esmaeili SA, Khorasani S, Tabasi N, et al. In vivo study: Th1-Th17 reduction in pristane-induced systemic lupus erythematosus mice after treatment with tolerogenic Lactobacillus probiotics. J Cell Physiol. 2018;234:642. doi:10.1002/jcp.26819
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  34. Yang Y, Hong Q, Zhang X, Liu Z. BD400 protects from collagen-induced arthritis through histidine metabolism. Front Immunol. 2025;16:1518181. doi:10.3389/fimmu.2025.1518181
  35. Wang CH, Yen HR, Lu WL, Ho HH, Lin WY, et al. Adjuvant Probiotics of subsp. AP-32, MH-68, and subsp. CP-9 Attenuate Glycemic Levels and Inflammatory Cytokines in Patients With Type 1 Diabetes Mellitus. Front Endocrinol (Lausanne). 2022;13:754401. doi:10.3389/fendo.2022.754401
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  37. Cardoso RS, Messora MR, Silva PHF, Oliveira LF, Leite-Panissi C, et al. Effects of subsp. HN019 on ligature-induced periodontitis in rats with experimental rheumatoid arthritis. Benef Microbes. 2020;11:33. doi:10.3920/BM2019.0038
  38. Salehipour Z, Haghmorad D, Sankian M, Rastin M, Nosratabadi R, et al. Bifidobacterium animalis in combination with human origin of Lactobacillus plantarum ameliorate neuroinflammation in experimental model of multiple sclerosis by altering CD4+ T cell subset balance. Biomed Pharmacother. 2017;95:1535. doi:10.1016/j.biopha.2017.08.117
  39. Ezendam J, de Klerk A, Gremmer ER, van Loveren H. Effects of Bifidobacterium animalis administered during lactation on allergic and autoimmune responses in rodents. Clin Exp Immunol. 2008;154:424. doi:10.1111/j.1365-2249.2008.03788.x
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